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Original Article
4 (
3
); 75-79
doi:
10.25259/JISH_14_2021

Role of individualized homoeopathic medicine in the treatment of gout - An observational study

Department of Case Taking and Repertory, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.
Department of Homoeopathic Materia Medica, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India.

*Corresponding author: Dr. Bikash Biswas, Department of Case Taking and Repertory, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India. bikash21592@gmail.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Biswas B, Mandal S. Role of individualized homoeopathic medicine in the treatment of gout - An observational study. J Intgr Stand Homoeopathy 2021;4:75-9.

Abstract

Objectives:

The objectives of the study were to evaluate the effects of homoeopathic treatment on patient distress, sociodemographic factors and outcomes in patients with gout.

Materials and Methods:

This was an observational study conducted using secondary data from hospital records, pathological reports, patient prescription sheet and the sociodemographic data from computerised records in Mahesh Bhattacharyya Homoeopathic Medical College and Hospital.

Results:

A total of 150 patients (94 men and 56 women) were included in the study. Gout was diagnosed based on clinical symptoms and laboratory reports. All patients were prescribed homoeopathic medicines along with dietary management. The patients were prescribed Lycopodium (n=22, 14.67%), Colchicum (n=17, 11.38%), Natrum sulph (n=18, 12%) and nitric acid (n=14, 9.38%) on the basis of totality and symptoms and individualisation. Improvement was assessed in four different categories: Marked, moderate, mild and no improvement. The patients improved clinically as well as pathologically. Uric acid (UA) reduction was marked in 26 (17.33%) patients, moderate in 67 (44.67%) patients and mild in 25 (16.67%) patients. Almost 125 (83.33%) among the 150 reported reduction in physical discomfort and have been doing well after treatment.

Conclusion:

This study showed that homoeopathic treatment is very effective in reducing clinical symptoms and serum UA levels in subjects having gout.

Keywords

Gout
Homoeopathy
Hyperuricaemia
Observational study

INTRODUCTION

Gout is a metabolic disease that primarily affects middle aged to elderly men and postmenopausal women.[1] Gout is among the most prevalent aetiologies of chronic inflammatory arthritis in the United States. The general prevalence of gout is 1–4% of the general population and can rise to 10% in men and 6% in women in those aged above 80 years. Globally, the occurrence is 2–6 times higher in men than in women.[2] Hyperuricaemia is the biologic hallmark of gout. In this condition, the plasma and extracellular fluids become supersaturated with uric acid (UA); under certain conditions, the UA crystallises and may result in a spectrum of clinical manifestations occurring singly or in combination.[1] Gout is characterised by deposition of monosodium urate (MSU) monohydrate crystals in the tissues.[3,4]

It is well known that reduced physical activity, higher intake of purine-rich food and alcoholic beverages as well as smoking cause hyperuricaemia.[5] Hyperuricaemia is the leading cause of gout.[1,6] Increased serum UA (SUA) level above a specific threshold (< 6 mg/dL in women and <7 mg/dL in men) is a requirement for the formation of UA crystals. Although hyperuricaemia is the main pathogenic process in gout, many people with hyperuricaemia do not develop gout or form UA crystals. In fact, only 5% of people with UA levels above 9 mg/dL develop gout. Thus, the diagnostic utility of measuring UA levels is limited.[7] Genetic predisposition also affects the incidence of gout.[8,9]

While MSU crystals can be deposited in all tissues, deposition mainly occurs in and around the joints, forming tophi. Early presentation of gout is often acute joint inflammation that is quickly relieved by nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine. Renal stones and tophi are late presentations. Lowering SUA levels below the deposition threshold through dietary modification and/or using SUA-lowering drugs are the main goal in the management of gout. This results in dissolution of MSU crystals, preventing further attacks.[10,11]

The most common presentation of gout is recurrent attacks of acute inflammatory arthritis (a red, tender, hot, swollen joint).[12] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases.[7] Other joints, such as the heels, knees, wrists and fingers, may also be affected.[3] Joint pain usually begins during the night and peaks within 24 h of onset.[3] This joint pain increases due to lower body temperature.[4] Other symptoms may rarely occur along with the joint pain, including fatigue and a high fever.[7,13]

Other blood tests commonly performed are white blood cell (WBC) count, electrolytes, kidney function and erythrocyte sedimentation rate (ESR). However, both the WBCs and ESR may be elevated due to gout in the absence of infection.[14,15] WBC counts as high as 40.0 × 109/l (40,000/mm3) have been documented.[13]

UA levels can be reduced by lowering the intake of alcohol, fructose, purine-rich foods, red meat, sea food, coffee and stimulants. Patients are advised to consume low-fat products such as yoghurt, fresh fruits and vegetables along with Vitamin C supplementation.[16]

Role of homoeopathy in cases of gout

The number of evidence-based studies on homoeopathic treatment of gout is very limited. An open-label observational trial to assess the effect of individualised homoeopathic medicine in patients with gout was found to have a positive result.[17]

A prospective, randomised, single-blind placebo-controlled study was conducted with an objective to evaluate improvement in the SUA level and visual analogue scale score of pain. The mean score reduction in the medicinal group was higher than in the placebo group; the difference was statistically significant.[18] It is being claimed that homoeopathic medicines are efficacious in treating gout but enough evidences are lacking.

This study was undertaken for that very purpose. We collected secondary data from hospital records and pathological reports to find out the degrees of improvement in cases of gout after administration of individualised homoeopathic medicines; and also the frequently indicated remedies [Table 1]. This has helped to state the effectiveness of homoeopathy in cases of gout.

Table 1: Most frequently prescribed medicines.
Frequently prescribed medicine No. of patients Percentage
Lycopodium n= 22 14.67
Nitric acid n=14 9.38
Natrum sulph n=18 12
Colchicum autumnale n=17 11.38
Medorrhinum n=7 4.67
Calcarea fluor n=13 8.67
Calcarea carb n=10 6.67
Sulphur n=8 5.33
Benzoic acid n=11 7.33
Pulsatilla n=9 6
Coffea cruda n=9 6
Rhus toxicodendron n=6 4
Thuja occ n=6 4

MATERIALS AND METHODS

Process of study

An observational study on homoeopathic treatment of gout was conducted. Individualisation of each case was done by evaluating the totality of symptoms with the help of a proper case taking proforma. Data collection was through the secondary method; data were obtained from laboratory records, case taking proforma and records – both paper and computer.

Study design

This was an observational cohort study.

Declaration of patient consent

Not applicable.

Inclusion criteria

  1. Patients suffering from chronic and acute gout with high UA levels (≥7 mg/dL)

  2. The gout had to be clinically apparent, with symptoms such as joint pains

  3. Patients aged 18–70 years, both sexes, all religions and socioeconomic status

  4. Patients undergoing treatment but without any improvement.

Exclusion criteria

The following criteria were excluded from the study:

  1. Patients already undergoing treatment with other system of medicine

  2. Patients with other systemic diseases such as high blood pressure and diabetes mellitus.

Study design

This study was conducted in the outpatient department of the Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Dumurjola, Howrah. A majority of the patients are from the lower socioeconomic strata. The study sample was retrospectively selected from patients with hyperuricaemia who underwent estimation of UA during a 9-month period from November 2018 to February 2021. Due to the COVID-19 lockdown, data from March 2020 to September 2020 were not included. All pathology data were provided by the pathology department.

A total of 150 patients had undergone UA estimation for the treatment of gout in the above-mentioned study period. Sociodemographic data were available only regarding patient sex, age, name and religion [Table 2]. The body mass index (BMI) was calculated using the height and weight that were measured for the pathology records. The patients were classified into different groups according to the BMI as per the WHO criteria for South Asia.[19]

Table 2: Patient characteristics patients with gout=150.
Sociodemographic features Numbers with percentage
Sex
Male 94 (62.67)
Female 56 (37.33)
Age (years)
18–30 18 (12)
31–45 99 (66)
46–70 33 (22)
BMI (kg/m2)
Underweight < 18 7 (4.67)
Normal 18–24.99 80 (53.33)
Overweight 25–29.99 47 (31.33)
Obese >30 16 (10.67)
Occupation
Labour 79 (52.66)
Housewife 64 (42.66)
Teacher 2 (1.33)
Sedentary jobs 5 (3.33)

BMI: Body mass index

Homoeopathic intervention

The homoeopathic medicine was selected on the basis of individualisation for each case with a proper totality of symptoms created using homoeopathic philosophy. Medicines [Table 3] were prescribed in the centesimal potency and dispensed by the hospital dispensary. The doses comprised six globules (size 10) to be taken on an empty stomach early in the morning. Repetition of doses and patient follow-up were conducted according to Kent’s second prescription.[3] The potencies varied according to the patients’ condition, susceptibilities and nature of disease. The follow-up interval was 2 weeks, 1 week in case of acute pain. UA levels were rechecked 4 weeks after symptoms ameliorated and compared with the pre-treatment values [Tables 4 and 5].

Table 3: Indications of the prescribed medicines.[20]
Medicine Indication
Lycopodium Chronic gout, with deposits in joints. Toes and fingers contracted. Worse in right side. Better by motion
Nitric acid Pain as from splinters. Sticking pain in toe. Pain appears and disappears quickly
Natrum sulph Gout. Worse in damp cold weather. Frequently changing position, worse left side
Colchicum Inflammation of great toe, gout in heel. Cannot bear to have it touched or moved. Worse motion, sundown to rise
Medorrhinum Gouty concentration. Heel and balls of feet tender. Finger joints enlarged. Worse from daylight to sunset, better at seashore, damp weather
Calcarea fluor Gouty enlargements of the joints of the fingers. Worse during rest, change of weather. Better by warm application
Calcarea carb Gouty nodosities. Swelling of joints. Worse cold weather, washing, better by dry climate, pressure
Sulphur Rheumatic gout with itching, with stiffness in joints. Worse standing, rest. Better by warm weather
Benzoic acid Rheumatic gout, nodes very painful, gouty deposits, swelling of wrist. Worse uncovering. Better by warmth
Pulsatilla Boring pain in heels, tensive pain. Better in open air, warm room. Worse from heat
Coffea cruda Over use of coffee causing rheumatic gout. Better warmth
Rhus toxicodendron Hot painful swelling of joints. Better by motion. Worse at night
Thuja occ Gout. Pain in heels. Tips of fingers swollen red. Cracking of joints. Worse at night, from heat. Better by while drawing up the limb
Table 4: UA level estimation.
Reduction value UA level (mg/dL) Number of patients Percentage
Marked reduction Below 6 mg/dL n=26 17.33
Moderate reduction Borderline: 6 mg/dL n=67 44.67
Mild reduction 6.5 mg/dL n=32 21.33
No change Above 7 mg/dL n=25 16.67

UA: Uric acid

Table 5: Degree of improvement after homoeopathic treatment.
Degree of improvement Clinical pictures Number of patients (%)
Marked improvement Pain in joints is completely gone. No episodes of pain. Patient doing very well after treatment. UA level normal 26 (17.33)
Moderate improvement Patient feels occasional low-intensity pain. UA level slightly raised. Otherwise, patient doing well 67 (44.67)
Mild improvement Pain occurs suddenly at night and but lower than before. UA level is 6.5–7 mg/dL 32 (21.33)
No improvement Same as before 25 (16.67)

UA: Uric acid

RESULTS

Treatment outcome was assessed on the basis of pathological report and symptomatic improvement of pain in joints and general well-being. Four categories of improvement were determined: Marked, moderate, mild and none. Complete reduction of joint pain with no functional disturbances and lower UA levels was considered marked improvement. Moderate improvement was defined as occasional lower intensity of joint pain with border line UA level. Mild improvement was defined as UA levels between 6.5 mg/dL and 7 mg/dL with sudden pain at night. No amelioration in symptoms and the UA level remaining the same as before treatment was defined as no improvement.

DISCUSSION

The various studies have shown that homoeopathic treatment was very successful in the treatment of gout. This study was done to confirm the same.

This is an observational study and results were obtained very quickly and the cost to carry out the study was minimal. There was also no risk of loss to follow up of patients. The frequently indicated homoeopathic remedies prescribed in case of gout were found out and this will help in treatment of more such cases. However, there were also a few limitations of this study – the study was based on secondary data and no patient interaction was done.

CONCLUSION

Homoeopathic treatment has a significant role to reduce UA levels and provide symptomatic relief in the treatment of patients with gout. Further studies, including randomised controlled trials and observational studies, are required to obtain a deeper knowledge of clinicopathological and Materia Medica correlations.

Acknowledgments

We thank the Principal, Administrator, Resident medical officers and the Pathology department staff of the Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Dumurjola, Howrah.

Declaration of patient consent

Patient’s consent not required as patients identity is not disclosed or compromised.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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